Clinical Pharmacokinetics of Triple Immunosuppression Scheme in Kidney Transplant (Tacrolimus, Mycophenolate Mofetil

Kidney transplantation is now firmly established as the treatment of choice for most patients with End Stage Renal Disease. The short-term outcomes of renal transplantation have dramatically improved over the past several decades; in a large part, this success is due to improvements in immunosuppression and post transplantation medical care. The goal of immunosuppressive strategies in transplantation is to deliver immunosuppression that result in long-term allograft and patient survival, while minimizing the complications of this immunosuppression. Tacrolimus has been one of the cornerstones of immunosuppressive strategies in clinical transplantation. Currently, regimens that are used for induction and maintenance therapy include the concomitant use of Mycophenolate Mofetil and Corticosteroids. The purpose of this chapter is to provide comprehensive and updated information, about the immunosuppressive drugs tacrolimus, mycophenolate mofetil and corticosteroids, which are used as triple immunosuppression scheme to the control of rejection of the transplanted organ.